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Cleopatra I Syra (Greek: Κλεοπάτρα ἡ Σύρα; c. 204 – 176 BC) was a princess of the Seleucid Empire, Queen of Ptolemaic Egypt by marriage to Ptolemy V of Egypt, and regent of Egypt during the minority of their son, Ptolemy VI, from her husband’s death in 180 BC until her own death in 176 BC.